Most sedating antidepressants

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Source: Best Health Magazine, September 2008 Most of these (among the most-prescribed antidepressants in Canada) work the same way, says Wende Wood, a psychiatric pharmacist with the Centre for Addiction and Mental Health in Toronto.They increase the availability of chemicals that enhance nerve impulse transmission and mood.Some antidepressants, though, are more effective and better tolerated than others, the findings showed.The researchers analyzed data from 522 trials -- published and unpublished -- that included more than 116,000 participants.Because it causes weight gain, it’s ideal for patients such as the elderly, or cancer patients.Pros: The SSRI least likely to have discontinuation symptoms, because it stays in the system for longer periods of time.Of the 21 antidepressants studied, all of them worked better than a placebo."In the short-term, for acute depression, antidepressants seem to work modestly," said study author Dr. He's a professor of disease prevention at Stanford University in California.

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Side effects: Nausea, insomnia, headaches, sexual dysfunction, jitteriness, dry mouth, drowsiness.

Side effects: Sedation, fatigue, dry mouth, constipation, increased appetite, weight gain.

Whom it may be suitable for: Depression sufferers with anxiety and insomnia: It’s the most sedating antidepressant.

Pros: An SNRI that’s generally well tolerated if started in low doses.

Side effects: Can cause jitteriness, anxiety, insomnia; or can have the opposite effect (somnolence).

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