Dating with muhammad
In 622, Muhammad left Mecca for an oasis then known as Yathrib.
This trip became known as the hejira, the flight from persecution in Mecca.
For example, he shifted the direction of prayers from Jerusalem to Mecca, made Friday his special day of prayer, and renounced the Jewish dietary laws (except for the prohibition on eating pork).
Originally, he said the Arabs were descendants of Abraham through his son Ishmael, but in the Koran Abraham's connection to the Jews is denied, with Muhammad asserting that Abraham is only the patriarch of Islam, not Judaism as well, because he "surrendered himself to Allah." One of the immediate consequences of Muhammad's frustration was the expulsion of two Jewish tribes from Medina and the murder of all the members of a third Jewish tribe (except for the women and children, who were sold into slavery).
The Jews began to distance themselves from Muhammad, however, when he became critical of their not recognizing him as a prophet.
Once it was clear the Jews would not accept him, Muhammad began to minimize or eliminate the Jewish influence on his beliefs.
The principles of Islam were developed over time and, as was the case with earlier men professing to be prophets, not everyone was willing to accept Muhammad's claim to be God's messenger.
Muhammad was attacking the way of life of the more powerful families in the Quraysh tribe, and they were not happy about it.
In addition to having to persevere the criticism of his views, he also suffered terribly when his wife and uncle died in the same year.
In short, he had her put to death for the death of the other Muslim - Bishr, who quickly died from the poisoning. Thereupon the apostle said, "Allah will not like to make His apostle suffer from it (pleurisy) because it indicates the possession of Satan, but (my disease is the result of) the morsel that I had taken along your son. He destroyed, tortured, murdered, plundered, and enslaved many people (ref Kitab al-Tabaqat al-Kabir, volume 2, page 134, 136, 137). A Jewish woman, whose family had been wiped out by Muhammad, put poison into a lamb and fed it to Muhammad and the other Muslims.
Muhammad ingested some of the poisoned lamb and began to feel it's effects.